The biological basis for poly-L-lactic acid-induced augmentation

Philipp Stein , Olga Vitavska , Peter Kind , Willi Hoppe , Helmut Wieczorek , Nanna Y. Schurer

PLLA-induced augmentation is most likely based on capsule formation orchestrating macrophages, (myo-)fibroblasts, and collagen type I and III fibres. We observed considerably slower degradation of PLLA particles than described previously. Thus PLLA partic

Adverse Reactions to Dermal Fillers: Review

NICHOLAS J. LOWE, MD, FRCP, FACS , C. ANNE MAXWELL, MB, CHB, AND RICKIE PATNAIK, MD

Different injectable products have highly divergent properties, associated risks, and injection requirements. The der- masurgeon should be suitably experienced to select and use these products correctly.

Safety of poly-L-lactic acid (New-Fill®) in the treatment of facial lipoatrophy: a large observation

Martin Duracinsky, Pascale Leclercq, Susan Herrmann, Marie-Odile Christen, Marc Dolivo, Cécile Goujard and Olivier Chassany

This study demonstrated, in real-life conditions and on a large sample, that PLLA injections were feasible, efficient, and safe when performed by trained physicians.

Randomized, Controlled, Multicentered, Double-Blind Investigation of Injectable Poly-L-Lactic Acid f

Krista Bohnert, BS, Andrew Dorizas, MD, Paul Lorenc, MD, and Neil S. Sadick, MD

At the 12-month follow-up, there was a statistically significant increase of skin elasticity and hydration in PLLA-treated subjects and a decrease in transepidermal water loss in both groups. Pigmentation, erythema, and pore size were significantly decre
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